HSV12AB
Herpes Simplex Virus (HSV) Type I and II Specific Antibody, IgG
EPIC Test Procedure Code: LAB3543
Synonyms:
HSVG
Performing Lab:
Referral Laboratory
Container Type:
Serum Gel (Preferred), Red Top
Specimen Type:
Serum
Preferred Volume:
0.6 mL
Minimum Volume:
0.4 mL
Specimen Processing:
Centrifuge and aliquot serum into plastic vial.
Store and Transport:
Refrigerated
Stability:
Refrigerated - 14 days
Frozen -14 days
Unacceptable Condition:
Gross Hemolysis: Reject
Gross Lipemia: Reject
Gross Icterus: Reject
Limitations:
Detection of IgG-class antibodies to herpes simplex virus (HSV) should not be used routinely as the primary means of
diagnosing HSV infection. For patients presenting with presumed acute infection with HSV, a clinical specimen (eg, oral,
dermal, or genital lesion) should be sampled and submitted for detection of HSV types 1 and 2 by polymerase chain
reaction.
Serum specimens collected too early in the course of infection may not have detectable levels of HSV IgG. In cases of
suspected early disease, a repeat serum specimen should be collected 14 to 21 days later and submitted for testing.
The presence of IgG-class antibodies to either HSV type 1 or 2 does not differentiate between remote infection or acute
disease.
HSV serology cannot distinguish genital from nongenital infections.
The predictive value of positive or negative results depends on the prevalence of disease and the pretest likelihood of
HSV-1 and HSV-2.
False-positive results may occur. Repeat testing, or testing by a different method, may be indicated in some settings (eg,
patients with low likelihood of HSV infection).
diagnosing HSV infection. For patients presenting with presumed acute infection with HSV, a clinical specimen (eg, oral,
dermal, or genital lesion) should be sampled and submitted for detection of HSV types 1 and 2 by polymerase chain
reaction.
Serum specimens collected too early in the course of infection may not have detectable levels of HSV IgG. In cases of
suspected early disease, a repeat serum specimen should be collected 14 to 21 days later and submitted for testing.
The presence of IgG-class antibodies to either HSV type 1 or 2 does not differentiate between remote infection or acute
disease.
HSV serology cannot distinguish genital from nongenital infections.
The predictive value of positive or negative results depends on the prevalence of disease and the pretest likelihood of
HSV-1 and HSV-2.
False-positive results may occur. Repeat testing, or testing by a different method, may be indicated in some settings (eg,
patients with low likelihood of HSV infection).
CPT Codes:
86695 - HSV 1 IgG Type Specific (EAP 30040501)
86696 - HSV 2 IgG Type Specific (EAP 30040502)
Test Schedule:
Monday through Friday
Turnaround Time:
1-3 days
Method:
Multiplex Flow Immunoassay (MFI)
Test Includes:
HSV Type 1 Ab, IgG, S (HS1G)
HSV Type 2 Ab, IgG, S (HS2G)
HSV Type 2 Ab, IgG, S (HS2G)
Reference Ranges:
Please refer to the performing lab report for applicable reference ranges