Jonathan D. Breshears, MD

Jonathan Breshears, MD, is a board-certified and fellowship-trained neurosurgeon with Saint Luke's Neurological and Spine Surgery. He specializes in the treatment of benign and malignant tumors involving the brain and skull base. He completed a fellowship in open and endoscopic skull base surgery at MD Anderson Cancer Center. He has special interest in pituitary tumors, acoustic neuromas, meningiomas, and other tumors of the brain and skull base. He believes in a patient-centered approach, and collaborates closely with other Saint Luke's oncology and skull base specialists to achieve the best possible outcome for each patient.

Traylor JI, Sheppard HE, Ravikumar V, Breshears JD, Raza SM, Lin CY, Patel SR, DeMonte F. Computational Drug Repositioning Identifies Potentially Active Therapies for Chordoma. Neurosurgery. Jan 13, 2021.
Habib A, Hanasono MM, DeMonte F, Haider A, Breshears JD, Nader ME, Gidley PW, Su SY, Hanna EY, Raza SM. Surgical management of Skull Base Osteoradionecrosis in the Cancer Population – Treatment Outcomes and Predictors of Recurrence: A Case Series. Operative Neurosurgery. Sept 15, 2020.
Breshears JD, DeMonte F, Ahmed H, Gidley PW, Raza SM. Management of Recurrent or Progressing Skull Base Chondrosarcomas: Predictors of Long-Term Outcomes. Journal of Neurological Surgery Part B: Skull Base. Feb 7, 2020.
Breshears JD, Morshed R, Theodosopoulos PV. In Reply: Residual volume and location predict progression after primary subtotal resection of sporadic vestibular schwannomas: a retrospective volumetric study. Neurosurgery. Nov 6, 2019.
Breshears JD, Morshed R, Molinaro A, McDermott MW, Cheung SW, Theodosopoulos PV. Residual volume and location predict progression after primary subtotal resection of sporadic vestibular schwannomas: a retrospective volumetric study. Neurosurgery. June 24, 2019. 
Breshears JD, Chang J, Molinaro A, Sneed PK, McDermott MW, Tward A, Theodosopoulos PV. Temporal dynamics of pseudoprogression after Gamma Knife radiosurgery for vestibular schwannomas - a retrospective volumetric study. Neurosurgery. Jan. 1, 2019. 84(1): 123-131. 
Breshears JD, Haddad AF, Viner J, Rau J, Sankaran S, McDermott MW. A Reduced Exogenous Steroid Taper (REST) for postoperative brain tumor patients – a case-control study. World Neurosurgery. Jan. 10 2019.
Breshears JD, Hamilton LS, Chang EF. Spontaneous neural activity in the superior temporal gyrus recapitulates tuning for speech features. Frontiers in Human Neuroscience. Sept. 18, 2018. 
Breshears JD, Southwell DG, Chang EF. Inhibition of manual movements at speech arrest sites in the posterior inferior frontal lobe. Neurosurgery. Dec. 12, 2018.
Chang J*, Breshears JD*, Molinaro A, Sneed PK, Theodosopoulos PV, Tward A. Impact of pre-treatment tumor growth on tumor control for vestibular schwannomas following Gamma Knife radiosurgery. Laryngoscope. Online Nov. 8, 2018.
Southwell DG, Breshears JD, McDermott MW. A method for cranial nerve XI silencing during surgery of the foramen magnum region. Operative Neurosurgery. Online May 18, 2018.
Dichter B, Breshears JD, Leonard M, Chang EF. The control of vocal pitch in human laryngeal motor cortex. Cell. June 28, 2018. 174 (1):21-31
Walcott BP, Breshears JD, Choudhri O, Lawton MT. Transcallosal- transchoroidal Fissure Approach for Resection of Third Ventricular Cavernous Malformation: 3-Dimensional Operative Video. Operative Neurosurgery. April 25, 2017.
Breshears JD, Osorio JA, Barani I, Cheung S, Theodosopoulos PV. Surgery after primary radiation treatment for sporadic vestibular schwannomas. Operative Neurosurgery. March 31, 2017.
Chang EF*, Breshears JD*, Raygor K, Lau D, Molinaro AM, Berger MS. Stereotactic probability and variability of speech arrest & anomia site in the language dominant hemisphere. JNS. online Feb 19, 2016.
Nicholson A, Breshears JD, Osorio JA. Clinical Correlation: Cauda Equina Schwannoma. AJNR. Nov 2015. 
Breshears JD, Rutkowski MR, McDermott MW, Cha S, Tihan T, Theodosopoulos PV. Surgical Management of Intracranial Neurenteric Cysts – The UCSF Experience. JNLS Skull Base. online June 15, 2015
Breshears JD, Ivan ME, Cotter JA, Bollen AW, Theodosopoulos PV, Berger MS. Primary glioblastoma of the trigeminal nerve root entry zone: case report. Journal of Neurosurgery. Jan 2015; 122(1):78-81
Osorio JA, Breshears JD, Arnaout O, Simon N, Hastings-Robinson A, Aleshi P, Kilot M. Ultrasound Guided Percutaneous Injection of Methylene Blue to Identify Nerve Pathology and Guide Surgery. JNS Focus. Sept 2015. 39(3).
Abla AA, McDougall C, Breshears JD, Lawton MT. Intracranial-to-Intracranial Bypass for Posterior Inferior Cerebellar Artery Aneurysms: Options, Technical Challenges, and Results in 35 Patients. JNS. Nov 2015. 13: 1-12.
Breshears JD, Molinaro A, Chang EF. A probabilistic map of the human ventral sensorimotor cortex (vSMC) using electrical stimulation." Journal of Neurosurgery. May 15, 2015;
Rutkowski MR, Breshears JD, Kunwar S, Aghi MK, Blevins LS. Approach to the Postoperative Patient with Cushing’s Disease. Pituitary. April 2015. 18(2) p232-237.
Jumper S, Breshears JD, Berger MS Gelfoam scaffold for vein prolapse during brain tumor surgery. World Neurosurgery. August 9, 2014.
Breshears JD, Osorio JA, Hoffman W, McDermott MW. Temporalis Muscle Suspension on Synthetic Cranioplasty: Technical Note. Cureus. Dec 28, 2014.
Breshears JD, Jiang B, Rowland NC, Kunwar S, Blevins LS. Use of conivaptan for management of hyponatremia following surgery for Cushing’s disease. Clinical Neurology and Neurosurgery. 2013
Rowland NC, Breshears JD, Chang EF. Neurosurgery and the dawning age of Brain-Machine Interfaces. Surgical Neurology International. Vol 4. Supp I. 2013.
Dario J. Englot, M.D., Ph.D., Jonathan D. Breshears, M.D., Peter P. Sun, M.D., Edward F. Chang, M.D., and Kurtis I.Auguste, M.D. Seizure outcomes after resective surgery for extra-temporal lobe epilepsy in pediatric patients. A systematic review. Journal of Neurosurgery: Pediatrics Aug. 2013, Vol 12-3 (126-133).
Bandt KS, Roland JL, Pahwa M, Hacker CD, Bundy DT, Breshears JD, Sharma M, Shimony JS, Leuthardt EC. The impact of high-grade glial neoplasms on human cortical electrophysiology. PLoS ONE. 12(3). March 2017.
Freudenburg ZV, Gaona CM, Sharma M, Bundy DT, Breshears JD, Pless RB, Leuthardt EC. Fast Scale Network Dynamics in Human Cortex Have Specific Spectral Covariance Patterns. PNAS. March 10, 2014.
Mitchell TJ, Hacker CD, Breshears JD, Szrama NP, Sharma M, Bundy DT, Pahwa M, Corbetta M, Snyder AZ, Shimony JS Leuthardt EC. A Novel Data-Driven Approach to Preoperative Mapping of Functional Cortex Using Resting State Functional Magnetic Resonance Imaging. Neurosurgery. Vol 73 (6). Dec. 2013. p969-983.
Roland JL, Hacker CD, Breshears JD, Gaona CM, Hogan ER, Burton H, Maurizio C, Leuthardt EC. Brain mapping in a patient with congenital blindness – a case for multimodal approaches. Frontiers in Human Neuroscience. July 31, 2013.
Eric C Leuthardt, Jarod Roland, Jonathan D. Breshears, Kathleen Bandt, Joshua Shimony. Listening to the Brain - New Techniques in Intraoperative Brain Mapping. Clinical Neurosurgery. Vol 60. 2013.
Breshears JD, Gaona CM, Roland JL, Sharma M, Bundy DT, Shimony JS, Rashid S, Eisenman LN, Hogan RE, Snyder AZ, Leuthardt EC. Mapping Sensorimotor Cortex Using Slow Cortical Potential Resting State Networks While Awake and Under Anesthesia. Neurosurgery. Aug. 1, 2012. 71 (2). 305-316.
Leuthardt EC, Pei XM, Breshears JD, Gaona MS, Sharma M, Freudenberg ZV, Barbour D, Schalk G. Temporal evolution of gamma activity in human cortex during an overt and covert word repetition task. Frontiers in Human Neuroscience. 2012. Vol 6.
Roland JL, Miller K, Freudenburg ZV, Sharma M, Smyth MD, Gaona CM, Breshears JD, Corbetta M, Leuthardt EC. The effect of age on human motor electrocortigraphic signals and implications for brain-computer interface  applications. Journal of Neural Engineering. June 10, 2011. 8(4).
Breshears JD, Gaona CM, Roland JL, Sharma M, Bundy DT, Freudenburg ZV, Limbrick DD, Smyth MD, Smart W, Leuthardt EC. Decoding Motor Signals from the Pediatric Cortex: Implications for Brain-Computer Interfaces in Children. Pediatrics. July 1, 2011. 7(128).
Leuthardt EC, Gaona CM, Breshears JD, Sharma M, Roland JL, Szrama N, Solis JM, Freudenburg ZF, Schalk G. Using the electrocorticographic speech network to control a brain-computer interface in humans. Journal of Neural Engineering. 2011. 8(3).
Gaona CM, Sharma M, Freudenburg ZV, Breshears JD, Bundy DT, Roland JL, Barbour D, Schalk G, Leuthardt EC. Nonuniform High-Gamma (60-500 Hz) Power Changes Dissociate Cognitive Task and Anatomy in Human Cortex. Journal of Neuroscience. Feb. 9, 2011. 31(6):2091-2100.
Breshears JD, Roland J, Sharma M, Gaona C, Freudenburg Z, Tempelhoff R, Avidan MS, Leuthardt EC. Stable and dynamic cortical electrophysiology of induction and emergence with propofol anesthesia. PNAS. Dec. 7, 2010. 107(49): 21170-75.
Wu, M; Wisneski, K; Schalk, G; Sharma, M; Roland, J; Breshears, J; Gaona, C; Leuthardt, E. Electrocorticographic Frequency Alteration Mapping for Extraoperative Localization of Speech Cortex. Neurosurgery. 66(2): E407-409 2010.
Liu Y, Sharma M, Gaona CM, Breshears JD, Roland JL, Freudenburg ZV, Weinberger KQ, Leuthardt EC. Decoding Ipsilateral Finger Movements from ECoG Signals in Humans. Neural Information Processing Systems (NIPS) Conference Proceedings 2010. Vancouver, B.C., Canada.
Breshears J, Sharma M, Anderson N, Rashid S, Leuthardt E. Electrocorticographic Frequency Alteration Mapping of Speech Cortex during an Awake Craniotomy: Case Report. Stereotactic and Functional Neurosurgery 88(1):11-15. 2009
Patents:
Leuthardt, EC, Breshears, JD. Brain Function Mapping. US Patent No. 20110295143 Dec 1, 2011.
Book Chapters:
Breshears JD, Sun PP, Auguste KI. Pediatric Intramedullary Spinal Cord Tumors. Pediatric CNS Tumors. Springer. 2016