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Pericarditis is a condition where the thin sac around the heart, the pericardium, becomes inflamed. The inflammation can cause fluid to build up around the heart keeping it from pumping blood effectively.

Narrowing in the arteries of the legs can cause peripheral artery disease, limiting the blood flow to legs and feet. This restriction in blood flow can cause non-healing sores, pain in the legs while walking, and, in some cases, amputation.