Clinical Trials

Breast Cancer 
An Open-label, Randomized Phase 3 Study of MK-2870 as a Single Agent and in Combination With Pembrolizumab Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer

Breast Cancer
A Phase 3, Randomized, Open-label Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) Followed by Carboplatin/Paclitaxel vs Chemotherapy, Both in Combination with Pembrolizumab as Neoadjuvant Therapy for Triple-Negative

Breast Cancer 
De-Escalation of Therapy in Early-Stage TNBC Patients Who Achieve pCR After Neoadjuvant Chemotherapy with Checkpoint Inhibitor Therapy

Women's Cardiovascular Health 
Peripartum Hypertension and Cardiac Assessment of Remodeling Evaluation (P-CARE)

Atrial Fibrillation | Coronary Artery Bypass Graft (CABG)
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation after CABG

Pericarditis
A Phase 2/3 Efficacy and Safety Study of KPL-387 Treatment in Participants with Recurrent Pericarditis.

Percutaneous Coronary Intervention (PCI)
REvascularization Choices Among under-Represented Groups Evaluation (The RECHARGE Trial)

Breast Cancer
An Interventional, Open-Label, Randomized, Multicenter, Phase 3 Study of PF-07248144 Plus Fulvestrant Compared to Investigator's Choice of Therapy in Adult Participants With Hormone Receptor-Positive, HER2-Negative Advanced/Metastatic Breast Cancer Whose Disease Progressed After Prior CDK4/6 Inhibitor-based Therapy

Breast Cancer
The effect of regular physical activity and virtual exercise intervention on physical functions, fatigue, mental health, and disease progression in Metastatic Breast Cancer (MBC)

Advanced Solid Tumors
First-in-Human Study of STX-478, a H1047X Mutation-specific PI3Kα Inhibitor as Monotherapy and in Combination with Other Antineoplastic Agents in Advanced Solid Tumor Patients Tumors

Women's Cardiovascular Health
Pregnancy Complications Leading to Cardiovascular Disease Outcomes Registry

Coronary Artery Disease
A randomized controlled study of the Prevail Drug-Coated Balloon in subjects with in-stent restenosis and a single arm prospectively enrolled study of the Prevail Drug-Coated Balloon for de novo lesions in small vessel disease (Prevail Global)

Cardiometabolic
A Phase III, Randomised, Double-blind, Placebo-controlled, Event-driven Study to Evaluate the Effect of Baxdrostat in Combination with Dapagliflozin Compared with Dapagliflozin Alone on the Risk of Incident Heart Failure and Cardiovascular Death in Participants with Increased Risk of Developing Heart Failure

Mitral Valve
Percutaneous or surgical Repair In Mitral prolapse And Regurgitation for ≥ 65 Year-olds

Heart Failure 
A Prospective, Multi-Center, Open Label, Randomized Control Clinical Trial Evaluating the Safety and Efficacy of the Cordella™ Pulmonary Artery Sensor System in New York Heart Association (NYHA) Class II -III Heart Failure Patients (PROACTIVE- HF-2 Trial)

Electrophysiology
Product Surveillance Registry (PSR) Platform Base Protocol

Aortic Stenosis
SAPIEN 3/SAPIEN 3 Ultra/SAPIEN 3 Ultra RESILIA Moderate AS PROGRESS Trial Access

Pancreatic Cancer
RASolute 304: A Phase 3 Multicenter, Open-label, Randomized, 2-Arm Study of Adjuvant Daraxonrasib versus Observation Following Curative Intent Therapy in Patients with Resected Pancreatic Ductal Adenocarcinoma (PDAC)
 

Women's Cardiovascular Health | Cardiomyopathy
Randomized Evaluation of Bromocriptine in Myocardial Recovery Therapy for Peripartum Cardiomyopathy (REBIRTH)

Heart Failure 
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients (REDEFINE-HF)

Heart Failure 
RELIVE Trial- Randomized Evaluation of Less Invasive Ventricular Enhancement

Aortic Valve
RESTORE Study (REdo tranScatheter aortic valve replacement for Transcatheter aOrtic valve failuRE)
 

Neurology | Ischemic Stroke
Statins use in intracerebral hemorrhage patients

Aortic Stenosis
Siegel Transcatheter Aortic Valve Replacement in patients with symptomatic severe aortic stenosis