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Steven Tinkham was always proud of his active lifestyle. A born athlete, he grew up to find passion in biking and bodybuilding. But by the time he reached his 40s, an undiagnosed condition was beginning to take its toll—one joint at a time.

While the CPAP machine is the most effective way to treat sleep apnea, some patients, like veteran David Cotter, can’t tolerate the mask that users have to wear at night.

As Sallie Wickens boarded the LifeFlight helicopter in Climax Springs, Missouri, in June 2012, she had no idea it would be the last leg of a journey that started when she was 5 years old.