Provider Profile

Saint Luke’s Care Member

Provider Profile

David M Safley, MD

Cardiology, Interventional Cardiology
Call to make an appointment 816-931-1883


Medical School
Tulane University School of Medicine, New Orleans, LA
Internal Medicine, Virginia Commonwealth University Health System (Medical College of Virginia), Richmond, VA
Cardiovascular Disease, Univ of Missouri - Kansas City School of Medicine, Kansas City, MO
Interventional Cardiology, University of Missouri - Kansas City School of Medicine, Kansas City, MO

Board Certifications

  • American Board of Internal Medicine - Subspecialty in Cardiovascular Disease
  • American Board of Internal Medicine - Subspecialty in Interventional Cardiology

Academic Titles

  • Associate Professor of Medicine, University of Missouri–Kansas City School of Medicine

Clinical Interests

  • interventional cardiology
  • peripheral vascular intervention
  • vein clinic
  • peripheral artery disease
  • clinical cardiology


Dr. Safley is co-medical director of the Imaging Core Lab. He grew up in Independence, Missouri.  After graduating from the University of Missouri-Columbia, he attended Medical School at Tulane University in New Orleans, LA.  Internal Medicine Residency was completed at the Medical College of Virginia in Richmond, and General and Interventional Cardiovascular Fellowships were completed at the Saint Luke’s Mid America Heart Institute/University of Missouri – Kansas City program. He joined Saint Luke's Cardiovascular Consultants in 2006.

During training, Dr. Safley developed an interest in coronary and peripheral vascular disease research that he has continued in practice. He is a clinical scholar at Saint Luke’s Mid America Heart Institute and an Associate Professor of Medicine at the University of Missouri–Kansas City School of Medicine.

Saint Luke's News

Better KC: Saint Luke's Receives Comprehensive Cardiac Center Certification
Achieving this national certification recognizes the excellence of care across the entire Saint Luke’s cardiac program and is reflective of the Saint Luke's Mid America Heart Institute’s commitment to quality and our pursuit of innovation and excellence in heart care.

Accepted Insurances

  • Aetna Better Health/KanCare (KS Medicaid)
  • Aetna Choice POS II Aexcel Local
  • Aetna Choice POS II Local
  • Aetna Elect Choice POS
  • Aetna Federal Employees Health Benefit Plan HMO
  • Aetna First Health Network (excluding limited benefit plans)
  • Aetna HMO
  • Aetna HMO Local
  • Aetna Managed Choice POS
  • Aetna Medicare Plan (Medicare Advantage HMO, PPO)
  • Aetna Missouri Preferred
  • Aetna Open Choice PPO
  • Aetna Select HMO
  • Aetna Select Local HMO
  • Aetna Signature Administrators (ASA) HMO, POS, PPO
  • Aetna UAW Retiree Medical Benefits Trust (Medicare Advantage HMO, PPO)
  • Aetna Workers Comp
  • Aetna/Coventry Advantra Freedom Medicare Advantage PPO
  • Aetna/Coventry Advantra Freedom Plus Medicare Advantage PPO
  • Aetna/Coventry Advantra Total Care Medicare Advantage PPO
  • BCBS of Kansas (call provider)
  • BCBS of Kansas Blue Choice Preferred Care Blue PPO
  • BCBS of Kansas City Blue Select Plus (UCMO and City of KCMO)
  • BCBS of Kansas City Federal PPO
  • BCBS of Kansas City Freedom Network PPO
  • BCBS of Kansas City Freedom Network Select PPO
  • BCBS of Kansas City Preferred Care
  • BCBS of Kansas City Preferred Care Blue
  • BCBS of Kansas City Traditional
  • BCBS of Kansas Federal
  • BCBS of Kansas Traditional
  • BCBS of Michigan Medicare Advantage PPO
  • Blue KC Medicare Advantage HMO
  • Blue KC Medicare Advantage PPO
  • Century Health Solutions (PPO)
  • Cigna HMO
  • Cigna National POS Open Access
  • Cigna OAP
  • Cigna PPO
  • CompResults/CompAlliance (WC) PPO
  • Health Choice of Northwest Missouri (PPO)
  • Home State Health Plan Missouri Medicaid (Missouri practices)
  • Humana Choice PPO - Medicare Advantage
  • Humana ChoiceCare PPO
  • Humana Community HMO - Medicare Advantage
  • Humana Gold Choice Medicare Advantage PFFS
  • Humana Gold Plus HMO - Medicare Advantage
  • Humana Gold Plus HMO SNP - Medicare Advantage
  • Humana Kansas City PPOx
  • Humana National POS-Open Access Plans
  • Humana PPO
  • Humana Preferred PPO
  • Humana SmartExpress PPO
  • Humana SmartNet PPO
  • Humana SmartSuite PPO
  • HumanaOne PPO
  • Integrated Health Plan PPO
  • Kansas Medicaid
  • Medica Connect
  • Medica Select
  • Medicare
  • Missouri Care Health Plan - Missouri Medicaid (MO practices only)
  • MultiPlan/PCHS (PPO)
  • Occupational Health Management PPO (WC)
  • OHARA Managed Care (WC)
  • Private Healthcare Systems PPO
  • ProviDRs Care Network PPO (formerly WPPA)
  • Sunflower State Health Plan Kansas Medicaid (Kansas practices)
  • Triwest Veterans Affairs Patient Centered Community Care
  • United Healthcare - All Savers Insurance Company POS
  • United Healthcare - Choice HMO
  • United Healthcare - Choice Plus POS
  • United Healthcare - Community Plan (KS Practices, KanCare, Kansas Medicaid)
  • United Healthcare - Community Plan (MO practices, Missouri Medicaid)
  • United Healthcare - Definity Health Reimbursement Account POS
  • United Healthcare - Definity Health Savings Account POS
  • United Healthcare - Golden Rule HMO (HMO & PPO)
  • United Healthcare - Indemnity
  • United Healthcare - Managed Indemnity
  • United Healthcare - Options PPO
  • United Healthcare - Select HMO
  • United Healthcare - Select Plus POS
  • United Healthcare - United Health One (Short Term Medical)
  • UnitedHealthcare - AARP Medicare Complete Choice PPO
  • UnitedHealthcare - AARP Medicare Complete HMO
  • UnitedHealthcare - AARP Medicare Complete PPO
  • UnitedHealthcare - Dual Complete SNP PPO
  • UnitedHealthcare - Group Medicare Advantage PPO
  • UnitedHealthcare - Medicare Complete PPO
  • UnitedHealthcare - Medicare Gold SNP PPO
  • UnitedHealthcare - Medicare Silver SNP PPO



1. Safley D, Amin A, House J, Baklanov D, Mills R, Giersiefen H, Bremer A, Marso S. Comparison of Costs Between Transradial and Transfemoral Percutaneous Coronary Intervention: A Cohort Analysis from the Nationwide Premier Perspective Hospital Database.  Accepted for Publication Am J Cardiol.
2. Smolderen K, Safley D, House J, Spertus J, Marso S. Percutaneous Transluminal Angioplasty: Association Between Depressive Symptoms and Diminished Health Status Benefits.  Vascular Medicine 2011 Aug 4; 16(4):260-266.
3. Allen D, Lindsey J, Kennedy K, Marso S, Safley D.  Arterial Closure Device Utilization and Bleeding Complication Reduction in Patients Undergoing Percutaneous Coronary Intervention.  Am J Cardiol. 2011 Jun 1;107(11):1619-23.
4. Safley D, Koshy S, Grantham J, Bybee K, House J, Kennedy K, Rutherford B.  Changes in myocardial ischemic burden following percutaneous coronary intervention of chronic total occlusions.  Catheter Cardiovasc Interv. 2011 Mar 16.
5. Safley D, Kennedy K, Stansby G, Flather M, Cohen D, Spertus J.  Prevalence and Predictors of Persistent Health Status Impairment in Patients Referred to a Vascular Clinic with Intermittent Claudication.  Eur J Vasc Endovasc Surg. 2011 Mar 2. 
6. Safley D, Lindsey J, Robertus K, House J, Mahoney E, Allen K, Cohen D.  In-Hospital Outcomes and Cost Comparison of Femoropopliteal Reopening Strategies.  Cardiovasc Revasc Med. 2011 Jan 25.
7. Allen KB, Grantham A, Laster S, Safley D, Kao A, Stuart S, Pak A, Stewart J, Borkon AM.  Transmyocardial Laser Revascularization: Evidence-based Outcomes and Future Directions.  Cardiac Surg Today 2010;4(3):89-100.
8. Stolker JM, Mahoney EM, Safley DM, Pomposelli FB, Yadav JS, Cohen DJ, on behalf of the SAPPHIRE Investigators.  Health-Related Quality of Life Following Carotid Stenting vs. Endarterectomy: Results from the SAPPHIRE Trial.  JACC Cardiovasc Interv. 2010 May;3(5):515-23.
9. Safley DM, House JA, Marso SP, Grantham JA, Rutherford BD. Improvement in survival following successful percutaneous coronary intervention of coronary chronic total occlusions: variability by target vessel.  JACC Cardiovasc Interv. 2008 Jun;1(3):295-302.
10. Frutkin AD, Mehta SK, Patel T, Menon P, Safley DM, House J, Barth CW, Grantham JA, Marso SP.  Outcomes of 1,090 consecutive, elective, nonselected percutaneous coronary interventions at a community hospital without onsite cardiac surgery. Am J Cardiol 2008 Jan 1;101(1):53-7.
11. Safley DM, House JA, Daniel WC, Laster SB, Spertus JA, Marso SP.  Health Status Recovery Following Peripheral Endovascular Revascularization, Circulation 2007 Feb 6;115(5):569-75.
12. Marso SP, Safley DM, House JA, Tessendorf TT, Reid KJ, Spertus JA.  Suspected Acute Coronary Syndrome Patients with Diabetes and Normal Troponin-I Levels are at Risk for Early and Late Death: Identification of a New High-Risk ACS Population. Diabetes Care 2006 Aug;29(8):1931-2.
13. Safley DM, House JA, Rutherford BD, Marso SP.  Success Rates of Percutaneous Coronary Intervention of Chronic Total Occlusions and Long-Term Survival in Patients with Diabetes Mellitus.  Diab Vasc Dis Res 2006 May;3(1):45-51.
14. Safley DM, Marso SP.  Diabetes and percutaneous coronary intervention in the setting of an acute coronary syndrome. Diab Vasc Dis Res 2005 Oct;2(3):128-135.
15. Spertus J, Safley DM, Garg M, Jones PG, Peterson ED.  The Influence of Race on Health Status Outcomes One Year after an Acute Coronary Syndrome. J Am Coll Cardiol 2005 Nov 15;46(10):1838-44.
16. Vaglio J, Safley DM, Rahman M, Kosiborod M, Jones P, Thompson RC, Krumholz HM, Spertus JA. Relation of Anemia at Discharge to Survival After Acute Coronary Syndromes.  Am J Cardiol 2005 Aug 15;96(4):496-9.
17. Marso SP, Murphy JW, House JA, Safley DM, Harris, WS.  Metabolic Syndrome Mediated Inflammation following elective percutaneous coronary intervention.  Diabetes Vasc Dis Res 2005;2:31-6.
18. Safley DM, Awad A, Sullivan RA, Sandberg KR, Mourad I, Boulware M, Merhi W, McCullough PA.  Changes in B-Type Natriuretic Peptide Levels in Hemodialysis and the Effect of Depressed Left Ventricular Function.  Adv Chronic Kidney Dis 2005 Jan;12(1):117-24.
19. Safley DM, Marso SP.  Diabetes and Percutaneous Coronary Revascularization in the Drug-Eluting Stent Era.  Herz 2004;29(5):1-9.
20. Safley DM, House JA, Borkon, AM, Spertus JA.  A Comparison of Quality of Life after Repeat Coronary Artery Bypass Surgery Compared with Initial Surgery.  Am J Cardiol 2004 Aug 15;94(4):494-7.
21. Safley DM, McCullough PA. The Emerging Role of Brain Natriuretic Peptide in the Management of Acute and Chronic Heart Failure in Outpatients.  Heart Failure Monitor 2003;4:13-20. 
22. Safley DM, McCullough PA. Antiphospholipid Syndrome with Renal Artery Embolism: Case Report.
Rev Cardiovasc Med 2002 Fall;3(4):196-201.

On Staff At

  • Anderson County Hospital
  • Hedrick Medical Center
  • Saint Luke's Cushing Hospital
  • Saint Luke's East Hospital
  • Saint Luke's Hospital of Kansas City
  • Saint Luke's North Hospital–Barry Road
  • Saint Luke's North Hospital–Smithville
  • Saint Luke's South Hospital
  • Wright Memorial Hospital