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Steven Tinkham was always proud of his active lifestyle. A born athlete, he grew up to find passion in biking and bodybuilding. But by the time he reached his 40s, an undiagnosed condition was beginning to take its toll—one joint at a time.

In 2017, Charles Koslowsky, 70, learned he had a rare form of pancreatic cancer. It had metastasized to his liver.

David Hartzler was the epitome of health. A former collegiate swimmer, he had continued the sport into adulthood. Three times a week, the Lawrence, Kan., resident swam 3,000 meters with the Lawrence Masters Swim Club.