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Steven Tinkham was always proud of his active lifestyle. A born athlete, he grew up to find passion in biking and bodybuilding. But by the time he reached his 40s, an undiagnosed condition was beginning to take its toll—one joint at a time.

For three years, Linda Braxdale endured throbbing pain in her lower back and down her left leg. The pain and frustration often left her feeling helpless and defeated—and reduced to tears.

Beth O’Connor hoped the sharp, searing pain that started in her chest and shot down to her belly was labor pangs and not her aortic artery coming apart.