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Steven Tinkham was always proud of his active lifestyle. A born athlete, he grew up to find passion in biking and bodybuilding. But by the time he reached his 40s, an undiagnosed condition was beginning to take its toll—one joint at a time.

Beth O’Connor hoped the sharp, searing pain that started in her chest and shot down to her belly was labor pangs and not her aortic artery coming apart.

David Hartzler was the epitome of health. A former collegiate swimmer, he had continued the sport into adulthood. Three times a week, the Lawrence, Kan., resident swam 3,000 meters with the Lawrence Masters Swim Club.