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Steven Tinkham was always proud of his active lifestyle. A born athlete, he grew up to find passion in biking and bodybuilding. But by the time he reached his 40s, an undiagnosed condition was beginning to take its toll—one joint at a time.

In 2017, Charles Koslowsky, 70, learned he had a rare form of pancreatic cancer. It had metastasized to his liver.

When Debbie O’Neal was diagnosed with heart failure at 75, she feared her life was ending. She was the same age that her mother had been when she died of heart disease.