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Steven Tinkham was always proud of his active lifestyle. A born athlete, he grew up to find passion in biking and bodybuilding. But by the time he reached his 40s, an undiagnosed condition was beginning to take its toll—one joint at a time.

Five years ago, 66-year-old Diane Hicks had a health scare that turned out to be a turning point for her entire life. She learned she needed to seriously consider a kidney transplant to improve her overall health and life expectancy.

For three years, Linda Braxdale endured throbbing pain in her lower back and down her left leg. The pain and frustration often left her feeling helpless and defeated—and reduced to tears.