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Steven Tinkham was always proud of his active lifestyle. A born athlete, he grew up to find passion in biking and bodybuilding. But by the time he reached his 40s, an undiagnosed condition was beginning to take its toll—one joint at a time.

As Sallie Wickens boarded the LifeFlight helicopter in Climax Springs, Missouri, in June 2012, she had no idea it would be the last leg of a journey that started when she was 5 years old.

David Hartzler was the epitome of health. A former collegiate swimmer, he had continued the sport into adulthood. Three times a week, the Lawrence, Kan., resident swam 3,000 meters with the Lawrence Masters Swim Club.