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Steven Tinkham was always proud of his active lifestyle. A born athlete, he grew up to find passion in biking and bodybuilding. But by the time he reached his 40s, an undiagnosed condition was beginning to take its toll—one joint at a time.

Five years ago, 66-year-old Diane Hicks had a health scare that turned out to be a turning point for her entire life. She learned she needed to seriously consider a kidney transplant to improve her overall health and life expectancy.

As Sallie Wickens boarded the LifeFlight helicopter in Climax Springs, Missouri, in June 2012, she had no idea it would be the last leg of a journey that started when she was 5 years old.