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Steven Tinkham was always proud of his active lifestyle. A born athlete, he grew up to find passion in biking and bodybuilding. But by the time he reached his 40s, an undiagnosed condition was beginning to take its toll—one joint at a time.

As 37-year-old Diamon Masterson watched his doctor study his CT scan results, he could tell from a puff of air that escaped the doctor’s mouth that the news was bad.

Shanon Wolfe's varicose vein troubles were more than cosmetic. Although her legs didn’t hurt at the end of the day, more and more often they felt heavy and tired. It began interfering with her kickboxing.